Dana-Farber Cancer Institute is looking for an exceptional candidate for a unique Research Assistant position. This position affords the exciting opportunity to be part of a research effort at Dana-Farber Cancer Institute aiming to delineate genomic aberrations in cancer biology and discover novel therapeutic targets. This role will use modern next generation sequencing techniques to characterize genomic and transcriptional heterogeneity including preparing samples for next-generation sequencing and computational analysis of the resulting datasets. He/she will use various model systems to test for drug responses and determine mechanisms of resistance to drugs, including novel immunotherapies. The research technician will be part of a multi-disciplinary team that evaluates new technologies and approaches to discover and validate novel systemic cancer biology.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

The candidate is expected to work largely independently after training, but will be closely mentored by the principal investigator and others.

Dana-Farber Cancer Institute provides a vibrant research environment with close links to top academic institutions across the Boston and Cambridge area and provide the potential for your contributions to be used and recognized worldwide.

• Learn, execute, further develop and analyze the data originating from next-generation sequencing and explore novel techniques / analyses of low input genomics including single-cell sequencing.

• Documents, compiles, and analyzes experimental protocols and data including running established computational pipelines on the command line.

• Handles cell culture of cancer cell lines and sensitive primary human cells. Uses established protocols and works closely with Broad and DFCI platforms, facilities, and collaborators.

• Uses wide assay of cell biology and molecular biology techniques to mechanistically characterize dependencies.

• Learns and executes a variety of in vitro functional bioassays, high dimensional phenotypic and flow cytometry readouts.

• Operates and maintains laboratory equipment to complete investigations.

• Prepares, orders, and maintains stocks of necessary reagents, solutions and supplies.

• Attends team meetings to share results, plan projects and experiments.

• Other related tasks as required.

• Strong interpersonal, communication, and organizational skills, including the ability to handle a variety of tasks in a fast-paced environment, large complex experiments, and large data sets, all of which demand great attention to detail.

• Proactive in identifying problems and solutions to address them.

• Must be an exceptional team player.

• Must possess a high level of initiative and the ability to work independently.

• Bachelor degree in biology, computational biology or related field required. 0-2 yrs of experience working in a scientific research setting a plus.

• Familiarity with the command line, linux systems and R is preferred.

• Familiarity of basic cell culture and molecular biology laboratory techniques, including recombinant DNA and protein biochemistry, strongly desired.

• Familiarity with fluorescent microscopy or flow cytometry is desirable.

If interested, after submitting your application, please contact the principal investigator:

Jens Lohr, MD PhD

Assistant Professor of Medicine, Harvard Medical School

Division of Hematologic Neoplasia and Center for Cancer Precision Medicine Dana-Farber Cancer Institute

Associate Member, Broad Institute

jensg_lohr@dfci.harvard.edu

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.